The Blind Lab

Press Highlights:

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     - Vanderbilt article highlighting JCI paper.

     - Ray wins Journal of Lipid Research Junior investigator Award.

     - Ray PI on Vanderbilt Trans-Institutional Program Award.

     - ASBMB Today Lipid News Article.

     - Ray interviewed by American Cancer Society Relay for Life.

     - Ray on an ESPN commercial for Jimmy V-week at 13:20.

     - Ray awarded Jimmy-V Foundation for Cancer Research V-Scholar Award.

     - Ray wins a JBC / Herb Tabor Young Investigator Award.

     - Structural Biology Knowledge Database Featured Article.

     - SLAC National Accelerator Lab News Feature Article.

     - Research Media Focus on Cancer.

     - Materials & Methods Blog post, "Why Study That". 

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Independent Lab  (Blind Lab members underlined):

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2020:

21. Corey D. Seacrist, Georg Kuenze, Reece M. Hoffmann, John E. Burke, Jens Meiler and Raymond D. Blind.

Structure, In Revision 2020. 

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2019:

20. Raymond D. Blind.

“Structural analyses of inositol phosphate second messengers bound to signaling effector proteins”,  Advances in Biological Regulation. 2019 Oct 11:100667. doi: 10.1016/j.jbior.2019.100667.   PDF

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19. Rachana Haliyur, Xin Tong, May Sanyoura, Shristi Shrestha, Jill Lindner, Diane Saunders, Radhika Aramandla, Greg Poffenberger, Sambra D. Redick, Rita Bottino, Nripesh Prasad, Shawn E. Levy, Raymond D. Blind, David M. Harlan, Louis H. Philipson, Roland W. Stein, Marcela Brissova, and Alvin C. Powers. "Human pancreatic islets expressing HNF1A variant have defective beta-cell transcriptional regulatory networks" Journal of Clinical Investigation.  2019 Jan 2;129(1):246-251. doi: 10.1172/JCI121994.  PDF

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18. Jamal M. Bryant and Raymond D. Blind.

"Nuclear Phosphoinositide Signaling in Human Health and Disease" Journal of Lipid Research 2019, Feb; 60(2):299-311. doi: 10.1194/jlr.R088518.  PDF

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2018:

17. Corey D. Seacrist and Raymond D. Blind.

"Crystallographic and kinetic analyses of human IPMK reveal disordered domains modulate kinase activity" Scientific Reports. 2018, Nov 12.  Biorxiv.  PDF

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16. Bree L. Hamman and Raymond D. Blind.

"Nuclear Phosphoinositide Regulation of Chromatin" Journal of Cellular Physiology  Jan 2018; 233(1):107-123. DOI 10.1002/jcp.25886.  PDF

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2017:

15. Mark K. Crowder*, Corey D. Seacrist* and Raymond D. Blind.

“Phospholipid Regulation of the Nuclear Receptor Superfamily” Advances in Biological Regulation  Jan 2017 63:6-14.  PDF

*Co-First Authors

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2016:

14. M. Merced Malabanan and Raymond D. Blind.

"Inositol Polyphosphate Multikinase in transcriptional regulation and nuclear inositide metabolism" Biochemical Society Transactions Review, 2016 Feb;44(1):279-85. PDF

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Ray's Postdoc & PhD work:

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2015:

13. Elena P. Sablin*, Raymond D. Blind*, Rubatharshini Uthayaruban, Ashley M. Deacon, Debanu Das, Holly A. Ingraham and Robert J. Fletterick. 

“Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket” Journal of Structural Biology  2015 Sep 25.  PDF

* Co-first Authors

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2014:

12. Raymond D. Blind, Elena P. Sablin, Kristopher Kuchenbecker, Hsiu-Ju Chiu, Ashley M Deacon, Debanu Das, Robert J Fletterick and Holly A. Ingraham. 

“The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1”  Proceedings of the National Academy of Sciences of the U.S.A.  2014 Oct 6; (doi:10.1073/pnas.1416740111).  PDF

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2013:

11. Raymond D. Blind.  

"Disentangling biological signaling networks by coupling signaling lipids to their modifying enzymes"  Advances in Biological Regulation  2013 Jan; 54:25-38  PDF

Corresponding author

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2012:

10. Raymond D. Blind, Miyuki Suzawa and Holly A. Ingraham. 

"Direct modification and regulation of a nuclear receptor-phosphoinositide complex by the inositol-lipid kinase IPMK and PTEN"  Science Signaling  2012 Jun; 5(229): ra44  (Featured Article on Cover)  PDF



10a. Holly A. Ingraham, Raymond D. Blind and Annalisa M. VanHook. 

"Science Signaling Podcast: 19 June 2012"  Sci Signal.  2012 Jun; 5(229): pc13  [DOI: 10.1126/scisignal.2003287]: http://tiny.cc/podcast13



9. Raymond D. Blind§, Inez Pineda-Torra, Yong Xu, H. Eric Xu and Michael J. Garabedian. 

"Ligand structural motifs decouple target promoter occupancy from transcriptional activation"  Biochem and Biophys Res Commun.  2012 Apr; 420(4): 839-44   PDF 

§ Corresponding author



2011:

8. Richard Whitby, Jozef Stec, Raymond D. Blind, Sally Dixon, Timothy M. Willson, Fang Chai, William J. Zuercher and Holly A. Ingraham. 

“Novel small molecule agonists of nuclear receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homolog-1 (LRH-1, NR5A2)”  J. Med. Chem  2011 Apr; 54(7): 2266-81  PDF



2010:

7. Brendan C. Mullaney, Raymond D. Blind, Carissa L. Perez, Ida C. Elle, Nils J. Faergeman, Marc R. Van Gilst, Holly A. Ingraham and Kaveh Ashrafi. 

“Regulation of fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25”.  Cell Metabolism  2010 Oct; 12(4): 398-410 PDF



2009:

6. Benjamin C. Lin*, Miyuki Suzawa*, Raymond D. Blind*, Sandra C. Tobias, Serdar E. Bulun, Thomas S. Scanlan and Holly A. Ingraham. 

“Stimulating GPR30 with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation”  Cancer Research  2009 Jul; 69: 5415-5422  PDF

* Co-first Authors



5. Elena P. Sablin*, Raymond D. Blind*, Irina N. Krylova*, Jared G. Ingraham, Fang Cai, Jon D. Williams, Robert J. Fletterick and Holly A. Ingraham. 

“Structure of SF-1 bound by different phospholipids: Evidence for regulatory ligands”  Mol Endo  2009 Jan; 23(1): 25-34  PDF

* Co-first Authors



2008:

4. Selma Omer, Giles Hickson, Stephanie Tache, Raymond Blind, Susan Masters, Helen Loeser, Kevin Souza, Charles Mkony, Haile Debas, and Patricia O’Sullivan. 

“Applying innovative educational principles when classes grow and resources are limited: biochemistry experiences at Muhimbili University of Health Sciences”  Biochem and Mol Biol Edu  2008 Nov; 36(6): 387-394  PDF



3. Weiwei Chen*, Thoa Dang*, Raymond D. Blind*, Zhen Wang, Claudio Cavasotto, Adam Hittleman, Inez Rogatsky, Susan K. Logan, Michael J. Garabedian.

"Glucocorticoid receptor phosphorylation differentially affects target gene expression"  Mol Endo  2008 May; 22(8): 1754-1766   PDF

* Co-first Authors



2. Raymond D. Blind and Michael J. Garabedian. 

"Specific phospho-isoforms of the glucocorticoid receptor are differentially recruited to endogenous target genes"  J Steroid Biochem and Mol Biol.  2008 Mar; 109(1-2): 150-7  PDF



1. Naima Ismali, Raymond Blind and Michael J. Garabedian. 

"Stabilization of the unliganded glucocorticoid receptor by TSG101" J Biol Chem.  2005 Mar 25; 280(12): 11120-6  PDF