Science Signaling Cover image for June 19, 2012, showing Nuclear Lipid Signaling through SF-1 bound to PIP2.  Image is a simulation, not a crystal structure.
Press Highlights:
     - Vanderbilt article highlighting JCI paper.
     - Ray wins Journal of Lipid Research Junior investigator Award.
     - Ray PI on Vanderbilt Trans-Institutional Program Award.
     - ASBMB Today Lipid News Article.
     - Ray interviewed by American Cancer Society Relay for Life.
     - Ray on an ESPN commercial for Jimmy V-week at 13:20.
     - Ray awarded Jimmy-V Foundation for Cancer Research V-Scholar Award.
     - Ray wins a JBC / Herb Tabor Young Investigator Award.
     - Structural Biology Knowledge Database Featured Article.
     - SLAC National Accelerator Lab News Feature Article.
     - Research Media Focus on Cancer.
     - Materials & Methods Blog post, "Why Study That". 

Independent Lab  (Blind Lab members underlined):
2019:
20. Raymond D. Blind.
Structural analyses of inositol phosphate second messengers bound to signaling effector proteins”,  Accepted review, Advances in Biological Regulation. Sep 2019  PDF
19. Rachana Haliyur, Xin Tong, May Sanyoura, Shristi Shrestha, Jill Lindner, Diane Saunders, Radhika Aramandla, Greg Poffenberger, Sambra D. Redick, Rita Bottino, Nripesh Prasad, Shawn E. Levy, Raymond D. Blind, David M. Harlan, Louis H. Philipson, Roland W. Stein, Marcela Brissova, and Alvin C. Powers. "Human pancreatic islets expressing HNF1A variant have defective beta-cell transcriptional regulatory networks" Journal of Clinical Investigation.  2019 Jan 2;129(1):246-251. doi: 10.1172/JCI121994.  PDF
18. Jamal M. Bryant and Raymond D. Blind.
"Nuclear Phosphoinositide Signaling in Human Health and Disease" Journal of Lipid Research 2019, Feb; 60(2):299-311. doi: 10.1194/jlr.R088518.  PDF
2018:

17. Corey D. Seacrist and Raymond D. Blind.

"Crystallographic and kinetic analyses of human IPMK reveal disordered domains modulate kinase activity" Scientific Reports. 2018, Nov 12.  Biorxiv.  PDF

16. Bree L. Hamman and Raymond D. Blind.

"Nuclear Phosphoinositide Regulation of ChromatinJournal of Cellular Physiology  Jan 2018; 233(1):107-123. DOI 10.1002/jcp.25886.  PDF

2017:
15. Mark K. Crowder*, Corey D. Seacrist* and Raymond D. Blind.
Phospholipid Regulation of the Nuclear Receptor Superfamily” Advances in Biological Regulation  Jan 2017 63:6-14.  PDF
*Co-First Authors
2016:

14. M. Merced Malabanan and Raymond D. Blind.

"Inositol Polyphosphate Multikinase in transcriptional regulation and nuclear inositide metabolismBiochemical Society Transactions Review, 2016 Feb;44(1):279-85. PDF

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Ray's Postdoc & PhD work:

2015:

13. Elena P. Sablin*, Raymond D. Blind*, Rubatharshini Uthayaruban, Ashley M. Deacon, Debanu Das, Holly A. Ingraham and Robert J. Fletterick. 

Structure of Liver Receptor Homolog-1 (NR5A2) with PIP3 hormone bound in the ligand binding pocket” Journal of Structural Biology  2015 Sep 25.  PDF

* Co-first Authors

2014:

12. Raymond D. BlindElena P. Sablin, Kristopher Kuchenbecker, Hsiu-Ju Chiu, Ashley M Deacon, Debanu Das, Robert J Fletterick and Holly A. Ingraham. 

The signaling phospholipid PIP3 creates a new interaction surface on the nuclear receptor SF-1”  Proceedings of the National Academy of Sciences of the U.S.A.  2014 Oct 6; (doi:10.1073/pnas.1416740111).  PDF

2013:

11. Raymond D. Blind.  

"Disentangling biological signaling networks by coupling signaling lipids to their modifying enzymes"  Advances in Biological Regulation  2013 Jan; 54:25-38  PDF

Corresponding author

2012:

10. Raymond D. Blind, Miyuki Suzawa and Holly A. Ingraham. 

"Direct modification and regulation of a nuclear receptor-phosphoinositide complex by the inositol-lipid kinase IPMK and PTEN"  Science Signaling  2012 Jun; 5(229): ra44  (Featured Article on Cover)  PDF



10a. Holly A. Ingraham, Raymond D. Blind and Annalisa M. VanHook. 

"Science Signaling Podcast: 19 June 2012"  Sci Signal.  2012 Jun; 5(229): pc13  [DOI: 10.1126/scisignal.2003287]: http://tiny.cc/podcast13



9. Raymond D. Blind§, Inez Pineda-Torra, Yong Xu, H. Eric Xu and Michael J. Garabedian. 

"Ligand structural motifs decouple target promoter occupancy from transcriptional activationBiochem and Biophys Res Commun.  2012 Apr; 420(4): 839-44   PDF 

§ Corresponding author



2011:

8. Richard Whitby, Jozef Stec, Raymond D. Blind, Sally Dixon, Timothy M. Willson, Fang Chai, William J. Zuercher and Holly A. Ingraham. 

Novel small molecule agonists of nuclear receptors Steroidogenic Factor-1 (SF-1, NR5A1) and Liver Receptor Homolog-1 (LRH-1, NR5A2)”  J. Med. Chem  2011 Apr; 54(7): 2266-81  PDF



2010:

7. Brendan C. Mullaney, Raymond D. Blind, Carissa L. Perez, Ida C. Elle, Nils J. Faergeman, Marc R. Van Gilst, Holly A. Ingraham and Kaveh Ashrafi. 

Regulation of fat uptake and storage by acyl-CoA synthase-3 is dependent on NR5A family nuclear hormone receptor nhr-25”.  Cell Metabolism  2010 Oct; 12(4): 398-410 PDF



2009:

6. Benjamin C. Lin*, Miyuki Suzawa*, Raymond D. Blind*, Sandra C. Tobias, Serdar E. Bulun, Thomas S. Scanlan and Holly A. Ingraham. 

Stimulating GPR30 with a novel tamoxifen analogue activates SF-1 and promotes endometrial cell proliferation”  Cancer Research  2009 Jul; 69: 5415-5422  PDF

* Co-first Authors



5. Elena P. Sablin*, Raymond D. Blind*, Irina N. Krylova*, Jared G. Ingraham, Fang Cai, Jon D. Williams, Robert J. Fletterick and Holly A. Ingraham. 

Structure of SF-1 bound by different phospholipids: Evidence for regulatory ligands”  Mol Endo  2009 Jan; 23(1): 25-34  PDF

* Co-first Authors



2008:

4. Selma Omer, Giles Hickson, Stephanie Tache, Raymond Blind, Susan Masters, Helen Loeser, Kevin Souza, Charles Mkony, Haile Debas, and Patricia O’Sullivan. 

Applying innovative educational principles when classes grow and resources are limited: biochemistry experiences at Muhimbili University of Health Sciences”  Biochem and Mol Biol Edu  2008 Nov; 36(6): 387-394  PDF



3. Weiwei Chen*, Thoa Dang*, Raymond D. Blind*, Zhen Wang, Claudio Cavasotto, Adam Hittleman, Inez Rogatsky, Susan K. Logan, Michael J. Garabedian.

"Glucocorticoid receptor phosphorylation differentially affects target gene expression"  Mol Endo  2008 May; 22(8): 1754-1766   PDF

* Co-first Authors



2. Raymond D. Blind and Michael J. Garabedian. 

"Specific phospho-isoforms of the glucocorticoid receptor are differentially recruited to endogenous target genes"  J Steroid Biochem and Mol Biol.  2008 Mar; 109(1-2): 150-7  PDF



1. Naima Ismali, Raymond Blind and Michael J. Garabedian. 

"Stabilization of the unliganded glucocorticoid receptor by TSG101J Biol Chem.  2005 Mar 25; 280(12): 11120-6  PDF

Publications:  

PubMed icon linke to all publications of the Blind Lab and Ray Blind Vanderbilt University
The Journal of Biological Chemistry Herb Tabor Award to Ray Blind Vanderbilt University.
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National Cancer Institute Transition to Indepedence Award to Ray Blind Vanderbilt University
National Institute of General Medical Sciences Institutional Research and Career Development Fellowship to Ray Blind, Vanderbilt University
Vanderbilt Diabetes Research and Training Center
Vanderbilt Ingram Cancer Center
Vanderbilt Institute of Chemical Biology
Vanderbilt Center for Structural Biology
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© 2019  Ray Blind